Together with the well-known roles of AChE andbutyrylcholinesterase(BChE) enzymes at the AD, it has also been shown that CA inhibitorsreduce amyloid β pathology and improve cognition by amelioratingcerebrovascular health and glial fitness.25 Studies have demonstrated that CA inhibitors such as acetazolamide(AZA) and methazolamide (MTZ) mitigate mitochondrial dysfunction andapoptosis triggered by amyloid β in both vascular and neuralcells. Here, ACHE is linked to Alzheimer disease.