Few studies have looked at the risk factors for the development of ILD in pSS and found that there was an increased risk with aging, cigarette smoking, ANA positivity,11 rheumatoid factor, C-reactive protein (CRP),12 and anti-ro-52 antibodies.13 There is limited data on the management of ILD in pSS, with no controlled trials. This evidence concerns the gene BTG3 and interstitial lung disease.