LAMP2 and infection: It is theorised that most of these infections can lead to the development of ANCA antibodies due to molecular mimicry and can persist over the time due to T and B cell stimulation caused by microbial superantigens.7,8 For example, it has been proven that some patients with ANCA-associated vasculitis create antibodies against the lysosome associated membrane protein-2 (LAMP-2), which is found in the neutrophils.