PNPLA2 and obesity due to melanocortin 4 receptor deficiency: Accordingly, this study showed that ATGL protein expression level was lower in WAT and BAT, while the plasma level of TG was reduced, which is specifically observed after systemic overexpression SLC25A28, suggesting that SLC25A28 regulates ATGL protein expression and posttranslational modification, thus affecting diet-induced obesity in mice.