We firstly performed RCS analysis and found a gradual increase in the disease progression risk of NPC patients with increasing expression of two key genes involved in the triglyceride anabolism (AGPAT1 and DGAT1), while a gradual decrease in the disease progression risk as observed with increasing expression of three key genes involved in the triglyceride catabolism (ATGL, HSL, and MGL) (Supplementary Figure 5). The gene discussed is LIPE; the disease is nasopharyngeal carcinoma.