PNPLA2 and nasopharyngeal carcinoma: We firstly performed RCS analysis and found a gradual increase in the disease progression risk of NPC patients with increasing expression of two key genes involved in the triglyceride anabolism (AGPAT1 and DGAT1), while a gradual decrease in the disease progression risk as observed with increasing expression of three key genes involved in the triglyceride catabolism (ATGL, HSL, and MGL) (Supplementary Figure 5).