It has been shown that a strong up-regulation of CCL21 takes place in correlation with the presence of a high number of activated T cells infiltrating the glands, which suggested a prominent role for CCL21 in the SS-associated lymphomagenesis by recruiting and chronically activating T cells, which, once stimulated, provide a stimulus for the expansion and survival of B cells within the reaction zone (56). Here, CCL21 is linked to synovial sarcoma.