A previous study showed that activation of the NF-κB2 pathway in (aly)/aly mice negatively regulates TGF-β signaling, whereas TGF-β upregulates the expression of CXCR4 and regulates the migration of T cells toward autoimmune targets, leading to damage similar to that seen in the early histopathological stages of SS (132). This evidence concerns the gene CXCR4 and synovial sarcoma.