Among the HCC patients, no mutations were observed in twelve other regulators, namely DNMT3B, MBD3, MBD4, ZBTB4, UHRF1, UHRF2, UNG, NTHL1, SMUG1, MBD2, ZBTB33 and QSER1 (Figure 2A). Here, MBD3 is linked to hepatocellular carcinoma.