Among the HCC patients, no mutations were observed in twelve other regulators, namely DNMT3B, MBD3, MBD4, ZBTB4, UHRF1, UHRF2, UNG, NTHL1, SMUG1, MBD2, ZBTB33 and QSER1 (Figure 2A). The gene discussed is UHRF1; the disease is hepatocellular carcinoma.