Notably, HCC tissues presented significantly increased expression of QSER1, MBD3, UNG, DNMT3B, DNMT3A, SMUG1, MBD4, DNMT1, MBD2, TET1, TDG, MBD1, UHRF2, MECP2, ZBTB38, ZBTB33, TET3 and UHRF1. Only NTHL1 was expressed at significantly lower levels in HCC tumor tissue. The gene discussed is MBD4; the disease is neoplasm.