EFHD2 and acne: Acne comorbidities suggest that diabetes mellitus is closely related to acne, and it has been found that SCH C can attenuate diabetic nephropathy by regulating macrophage M1 to M2 polarisation via Swiprosin-1/IFN-γ-Rβ, which could also potentially serve as a future target for SCH in the treatment of acne (137).