For the treatment of AIIRD-MAS, there is also a lack of specific guidelines, and treatment often references medications used for HLH, including traditional agents such as glucocorticoids, etoposide, cyclosporine or tacrolimus, intravenous immunoglobulin (IVIG), plasma exchange (20), etc. or the combination use of biologics such as anakinra (21), IL-18 binging protein (IL-18BP) (22), MAS-825 (23), emapalumab (24), and JAK inhibitors (25). The gene discussed is IL18; the disease is macrophage activation syndrome.