The STK11 mutation defines a special subtype of lung adenocarcinoma (LUAD) patients, and emerging evidences suggested that STK11 alterations may be prognostic and/or predictive of therapeutic response, particularly in immune- and targeted therapy, and some studies demonstrated that loss of function caused by STK11 mutation was highly correlated with poor outcomes of NSCLC (9–11). This evidence concerns the gene STK11 and lung adenocarcinoma.