Mutations in the genes coding for isoprenoid synthase domain‐containing protein (ISPD), fukutin‐related protein (FKRP), and fukutin (FKTN) cause distinct forms of secondary dystroglycanopathies, ranging from the milder limb girdle muscular dystrophy (LGMD) to the severe multisystem Walker‐Warburg syndrome.1 This evidence concerns the gene CRPPA and limb-girdle muscular dystrophy.