Meanwhile, Ptprd is known as a tumor suppressor that is inactivated and mutated in glioblastoma and other human cancers (Veeriah et al., 2009) in addition to its role in presynapse maturation, controlling STAT3 signaling (Uhl and Martinez, 2019) which is involved in a broad range of cell differentiation (Hirano et al., 2000; Kortylewski et al., 2005; Li et al., 2020; Tomita et al., 2020). Here, STAT3 is linked to neoplasm.