In addition, such analyses should address the sex-effect and the gene dosage effect on phenotypes, analyses using female mice are absolutely needed because Slitrk4 is located on X chromosome both in mice and humans (Aruga et al., 2003) and there is a sex bias in the PTSD transcriptome analysis (Girgenti et al., 2021). This evidence concerns the gene SLITRK4 and post-traumatic stress disorder.