WWOX and osteosarcoma: We discovered that the expression of lncRNA WWOX-AS1 [17], which has confirmed antitumor effects, was remarkably low (with an average of 0.85) as depicted in Fig. 1B. Conversely, MALAT1 [18] (with an average of 12.95), lncRNA SNHG16 [19] (with an average of 11.56), lncRNA H19 [20](with an average of 11.76), and ALKBH5 [21] (with an average of 13.09), all known tumor promoters and have been confirmed higher expression in osteosarcoma samples and cells compared to normal samples and cells, expressed nearly as highly as SRSF1 in human osteosarcoma tissues (Fig. 1C-F).