For proteins implicated in the pathogenesis of AD and dementia, including amyloid beta precursor protein binding family B member 1 (APBB1IP), amyloid beta precursor like protein 1 (APLP1), amyloid beta precursor protein (APP), and microtubule associated protein tau (MAPT), only trends without statistical significance were observed in relation to AD-GRS. This evidence concerns the gene APBB1 and Alzheimer disease.