TM9SF2 may regulate the biosynthesis of glycosphingolipids by regulates the subcellular localization of globotriaosylceramide synthase [43].TM9SF2 may be an oncogene and a prognostic marker with high expression associated with poor prognostic in pancreatic adenocarcinoma and colorectal cancer [44, 45]. This evidence concerns the gene TM9SF2 and colorectal cancer.