Multifactorial binary regression analysis revealed that the presence of infection upon admission (P = 0.016, OR = 1.837, 95%CI: 1.121–3.012), CRP (P = 0.001, OR = 1.006, 95%CI: 1.002–1.010), β2-MG (P < 0.001, OR = 1.239, 95%CI: 1.145–1.340), chemotherapy (P < 0.001, OR = 4.599, 95%CI: 2.548–8.298), HSCT (P < 0.001, OR = 3.361, 95%CI: 1.964–5.752), and use of vasopressors (P < 0.001, OR = 4.837, 95%CI: 2.531–9.244) were independently associated with the development of AKI (Table 4). This evidence concerns the gene CRP and acute kidney injury.