EIF2AK2 and Nephropathy: For this purpose, we investigated the curative effect of Se given at doses of 0.3 mg/kg on kidney damage induced by HFCS for 6 weeks, with histological (caspase-3 and TNF-α), biochemical (oxidative stress markers), and PCR analyses (protein kinase R (PKR)–like endoplasmic reticulum kinase (PERK), ATF, CHOP, BCL-2, and caspase-9).