POLQ and acute myeloid leukemia: Analysis of training BEAT AML 2.0 database revealed that upregulation of several genes involved in RAD51-mediated HR (BRCA1, RAD51, RAD54L and RAD51AP1) and Polθ-dependent TMEJ (POLQ, FEN1 and TRIP13) were associated with worse prognosis (Fig. 2A).