KRAS and colorectal cancer: Statistics on RAS mutations in 17,993 cancer patients showed that the total mutation frequency of RAS genes was 22.58%, with KRAS mutations being the most frequent and most commonly observed in pancreatic cancer (685/842, 81.35%), colorectal cancer (85/175, 48.57%), and colon cancer (1609/3329, 48.33%) [11].