A multicenter retrospective cohort study of 216 Asian KRAS-mutant NSCLC patients analyzed by Lee et al. found that most patients were male (70.8%), Eastern Cooperative Oncology Group (ECOG) physical status scores were mostly 0–1 (92.1%), histological subtypes included adenocarcinoma (89.8%), squamous cell carcinoma (4.2%), and others (6.0%), and KRASG12D was the most common subtype (25.5%), mostly in never-smokers, suggesting that KRAS-mutant lung cancer in Asian patients may be driven by factors other than smoking [13]. This evidence concerns the gene KRAS and non-small cell lung carcinoma.