The results showed that AP2/ERF-ERF (CZG_jg5663), LIM (CZG_jg21577), and HB-HD-ZIP (CZG_jg17873) exhibited relatively high expression levels in the core region, possibly contributing to the difference in CRC peel between the core region and other regions (Fig. 7d). The gene discussed is PDLIM5; the disease is colorectal carcinoma.