In sepsis, the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome leads to the cleavage of Caspase 1 (the typical pathway) or Caspase 11 (the atypical pathway), thereby releasing interleukin (IL)-1β, IL-18, and HMGB1, and leading to pyroptosis8. This evidence concerns the gene HMGB1 and Sepsis.