Meanwhile Mechanistic studies suggest that flavonoids may counteract the pro-inflammatory effects produced by pathogen-associated molecular pattern (PAMP) proteins through a Toll-like receptor (TLR) response.32 In the present study, sinensetin, a flavonoid extracted from citrus fruits, was found to suppress alveolar bone resorption and inflammatory cytokine levels in periodontium induced by periodontitis in a novel mechanism by which Sin targets Bach1 via Bach1/OH-1 pathway. Here, PROS1 is linked to periodontitis.