Studies have found that people who are susceptible to ROS are more likely to develop periodontitis than those who have a normal response to ROS.5 Moreover, in periodontitis, bone destruction induced by excessive osteoclast formation and activation is mediated by the host immune and inflammatory response to the microbial challenge.6 BTB-CNC homology 1 (Bach1), a transcriptional factor, has always been a key role in response to oxidative stress. This evidence concerns the gene BACH1 and periodontitis.