SPI1 and Alzheimer disease: To further elucidate the underlying mechanism by which Spi1 regulates AD-related pathology, we utilized targeted and single-cell transcriptomics approaches and found that several immune pathways relevant to AD pathogenesis are regulated by Spi1. Collectively, our findings suggest that activating SPI1 or its downstream pathways may have the potential to protect against Aβ and other pathology.