Similar to the Spi1-knockdown study, to explore potential pathways that are regulated by SPI1-overexpression in the context of AD pathology, we performed transcriptomic profiling in the cortices of Spi1Tg/0;5XFAD and Spi1+/+;5XFAD mice using the NanoString mouse AD panel. Here, SPI1 is linked to Alzheimer disease.