Mitochondrial fission is mediated by the recruitment of dynamin-related protein 1 (Drp1), which is regulated by phosphorylation (S616) and dephosphorylation (S637).21 For several mechanisms underlying viral replication and the evasion of antiviral innate immune signalling, mitochondrial fusion is required.22,23 Recent evidence suggests that virus infections induce abnormal mitochondrial dynamics and perturb mitochondrial bioenergetics, crucial for viral propagation and the antiviral innate immune response.24,25. This evidence concerns the gene DNM1L and viral infectious disease.