EGFR and infection: EGFR has been reported as a co-factor for numerous virus entry processes, and the involvement of EGFR internalisation and transport to cellular organelles provides a favourable environment for virus replication.27–31,71–74 In this study, we showed that SARS-CoV-2 stimulates EGFR-mediated cell survival signal during the early stages of infection (Figs. 2b–d) and subsequently promotes mitochondrial EGFR translocation (Figs. 2e–g, Supplementary Fig. 5), contributing to the maintenance of abnormal mitochondrial bioenergetics.