While some reports have indicated a decrease in ΔΨm induced by the SARS-CoV-2 M protein.64 or by infection with live, whole SARS-CoV-2 virus in human hepatoma Huh7 cells or Vero E6, an interferon response-attenuated cell line,65 our findings reveal that SARS-CoV-2 increases ΔΨm through the SARS-CoV-2 RNA and nucleocapsid complex (Fig. 1b, c), leading to mitochondrial elongation (Fig. 1d, Supplementary Fig. 2a) during the early stages of infection. Here, MYOM2 is linked to infection.