Previously we searched for methylated tumor suppressor genes (TSGs) candidates in digestive cancers through epigenomic (CpG methylome) study and expression profiling of a paired colon cancer cell line (HCT116 and HCT116-DKO with double knock-out of DNMT1 and DNMT3B [25, 26]), and found a significant signal enrichment of CpG methylation at the FOXE1 promoter in HCT116, but not in DKO, suggesting that FOXE1 is methylated target in colorectal cancer. This evidence concerns the gene FOXE1 and colonic neoplasm.