The other HMGCR-IMNM patients with atypical dermal manifestations presented non-scaly red patches and lumps evolving into targetoid lesions on the back and neck (Fig. 1B, C), head and face (Fig. 1D), and extremities (Fig. 1E), which were considered to be erythema multiforme. This evidence concerns the gene HMGCR and erythema multiforme.