NFKB1 and cancer: In summary, accumulating research has indicated that γT, δT, γTE, and δTE can inhibit cancer hallmarks and enabling characteristics including uncontrolled cell proliferation, resistance to apoptosis, angiogenesis, and inflammation by blocking PCa-promoting signaling including NF-κB, 5-LOX, sphingolipids, and possibly cholesterol synthesis as well as epigenetic modulation (Figure 4).