Specifically, it has been shown that the minor allele of rs704 results in higher vitronectin protein concentrations, stronger binding of vitronectin to PAI-1, and less cell-surface binding than the major allele.16, 17 However, evidence also supports the involvement of SARM1. SARM1, a member of the TIR adaptor family, has been linked to the regulation of essential inflammatory pathways and implicated as a regulatory element in the interleukin-1 pathway in rheumatoid arthritis monocytes.18 This evidence concerns the gene VTN and rheumatoid arthritis.