(Sinha et al., 2018; Godoy et al., 2014) Lastly, bisphenols and phthalates, in particular BPA and MEHP, are capable of binding to glucocorticoid receptors, which regulate metabolic adaptation during stress, and chronic increases in glucocorticoid have been associated with metabolic syndrome. The gene discussed is NR3C1; the disease is metabolic syndrome.