,10 Apatinib has ideal efficacy in gastric cancer, esophageal cancer, lung cancer, liver cancer, colorectal cancer, etc.11sPD-1 is mainly expressed on the surface of activated T-cells, B-cells, and macrophages, and its ligands include sPD-L1 and s PD-L2. This evidence concerns the gene SPDL1 and colorectal cancer.