To study the functional role of IL-22Ra1 in experimental colitis, we utilized IEC-specific Il22Ra1 knockout mice (Il22Ra1IEC) as described.14,23,24 We validated reduced Il22Ra1 and Reg3g expression in the distal colon of Il22Ra1IEC mice (Figures 1A and S1A). The gene discussed is IL22RA1; the disease is colitis.