Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis (UC), is characterized by disruptions in the protective lining of the intestine and an abnormal immune response.1 The importance of interleukin (IL)-22 in IBD is highlighted by the fact that genes associated with IBD (IL-23R, IL-10R2, and STAT3) are connected to the function of this cytokine.2 IL-22 plays a crucial role in maintaining the integrity of the intestinal epithelial barrier and regulating the immune response in the gut.3 The gene discussed is IL22; the disease is Crohn disease.