Knockdown of HDAC10 in ccRCC cells caused a pronounced reduction in Notch Intracellular Domain (NICD) and recombination signal binding protein for immunoglobulin kappa J region (RBPJ) expression levels while a notable increase in PTEN levels, as shown in Fig. 4a. This evidence concerns the gene HDAC10 and nonpapillary renal cell carcinoma.