In conclusion, suppressing circPDK1 inhibits proliferation and invasion of PTX-resistant cells, accelerates apoptosis, and acts as a molecular sponge of miR-4731-5p to downregulate GIGYF1, promote PTX sensitivity of NSCLC cells, and thus inhibit tumor growth in vivo. This evidence concerns the gene GIGYF1 and non-small cell lung carcinoma.