DNM1L and pulmonary arterial hypertension: Marsboom Get al. (2012) showed that hypoxia-inducible factor-1α activation in pulmonary smooth muscle cells from human PAH leads to mitochondrial fission by phosphorylation of Drp1 at serine 616, and hypoxia-inducible factor-1α inhibition reduced Drp1 activation, prevented fission, and reduced pulmonary smooth muscle cells proliferation.