WNK3 and neuropathy: In common with yeast Prs gene products, lack of Prs proteins can have detrimental effects on the human body specifically, decreased Prs activity has been linked to neuropathies (Lenherr et al. 2021; Meng et al. 2019; Nishikura et al. 2019; Puusepp et al. 2020; Synofzik et al. 2014).