NEFL and Alzheimer disease: Although neurofilament light chain (NfL), a marker of neuroaxonal degeneration, may not serve as an ideal standalone diagnostic marker for AD (Benkert et al., 2022; Karantali et al., 2022; Mattsson et al., 2017; van der Ende et al., 2022), it is useful for monitoring and predicting disease severity (Jung and Damoiseaux, 2024).