MAPT and tauopathy: Acetylation at K274, K280, and K281 disrupts the physiological functions of tau, impairing its interaction with microtubules and leading to its mislocalization and pathological aggregation, which contributes to synaptic deficits in tauopathies (Cohen et al., 2011; Sohn et al., 2016; Tracy et al., 2016).