Furthermore, specific PTMs in soluble tau—Ub-K369 and Ub-K343 for 4R-tau and Ac-K311 and P-S184 + P-S185 for 3R-tau—were identified as key discriminators between 4R- and 3R-tauopathies (Kyalu Ngoie Zola et al., 2023). This evidence concerns the gene MAPT and tauopathy.