CDK5 and Alzheimer disease: Key kinases, such as glycogen synthase kinase 3β (GSK3β), c-JUN N-terminal kinase (JNK), and cyclin-dependent kinase 5 (CDK5), are upregulated in the AD brain (Shukla et al., 2012; Tell and Hilgeroth, 2013; Yarza et al., 2015).