MAPT and Alzheimer disease: Various tauopathies, including AD, chronic traumatic encephalopathy (CTE), CBD, PiD, and PSP, are characterized by distinct tau fold patterns, highlighting the diversity of tau pathology (Falcon et al., 2018a, 2018b, 2019; Fitzpatrick et al., 2017; Shi et al., 2021b; Zhang et al., 2020).