MAPT and tauopathy: According to experimental models, intracerebral injection of brain extracts containing tau aggregates into tau transgenic mice induces NFT formation and pathological spread (Ahmed et al., 2014; Clavaguera et al., 2009), a phenomenon also observed with brain extracts from human tauopathies (Boluda et al., 2015; Clavaguera et al., 2013).