SOX2 and cancer: In addition, similar cancer biomarkers, including (CEA) [149], sex-determining region Y-box 2 (SOX2) [150], multidrug resistance (MDR) [151], and oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OhdG) [152] play a remarkable role in the progression of various cancers, and they are already developed as the targets for cancers diagnosis.