Additionally, an improved SERS with fabricating Raman reporters to silver NP films (AgNFs), so the DNA probes for a MicroRNA 223 (miR-223) and an α-Fetoprotein (AFP) antibody can be covalently bound to Raman reporter domains for the detection of miR-223 and AFP, which are specific biomarkers of liver cancer [126]. The gene discussed is AFP; the disease is liver cancer.