Compared to free IL-10, IL10-NP significantly reduces airway hyperresponsiveness and T-helper 2 /T-helper 17 cell cytokines induced by house dust mite (HDM) in a mouse model and inhibits the increase of neutrophils and eosinophils in the airways, making it a potential treatment for allergic airway diseases [85]. This evidence concerns the gene IL10 and airway hyperresponsiveness.