There are still many adipokines and cytokines whose involvement in the pathogenesis of MASLD and MASH is still unclear, including resistin, TNF-α, IL-6, IL-1β (interleukin 1β), IL-23 (interleukin 23), and extracellular matrix metalloproteinases (more specifically, gelatinase). The gene discussed is IL37; the disease is metabolic dysfunction-associated steatohepatitis.