Similar findings were observed with Bifidobacterium longum PI10, Bifidobacterium animalis, and Lactobacillus gasseri for 12 weeks, where the selected probiotics decreased body weight gain, fat deposition, obesity-linked metabolic dysfunction, and pro-inflammatory adipokines (IL-10 and leptin) [13]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.