Another polymorphism with proven functionality in vascular dysfunction is rs6511720 of the Low-Density Lipoprotein Receptor (LDLR) gene, for which a recent study has shown a significant association with susceptibility to coronary artery disease, as well as with regression of carotid intima-media thickness and changes in plasma lipids during rosuvastatin therapy [60]. This evidence concerns the gene LDLR and coronary artery disorder.