TLR2 and infection: At 24 h post-infection, there was a powerful upstroke in the relative expression of CYP27B1 and CAMP in MAP-infected THP-1 macrophages following TLR2 siRNA transfection with an average increase of 5.55 ± 0.82 and 24.47 ± 6.41 folds, respectively (p-value < 0.01) (Figure 2A,C).