Additionally, treatment with 25 and 50 mg/kg of syringic acid increased the mRNA expression of heme oxygenase-1 (Ho-1), NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1), and NRF2 in colon tissue in acetic acid-induced colitis rats [30]. Here, NFE2L2 is linked to colitis.