NOS3 and endothelial dysfunction: In young male Sprague–Dawley (SD) rats, supplementation with sea-buckthorn berries (7–28 mg/kg) significantly improved the tolerance for hyperlipidemia, prevented endothelial dysfunction of the aorta by enhancing the activity of antioxidant enzymes, attenuating the levels of inflammatory cytokines such as TNF–α and IL–6, and decreased the level of eNOS, ICAM–1, and LOX–1 expression [24].