Consequently, the study proposed that 6-Shogaol, acting as an inhibitor of the cysteinyl leukotriene 1 receptor (CysLT1R) and cathepsin B (both implicated in the pathogenesis of AD), could act as a neuroprotective agent, preventing neuronal death and cognitive deficits [75]. Here, CYSLTR1 is linked to Cognitive impairment.