At the same time, it should be noted that for the Romanian population, until now, no similar study has been carried out regarding the relationship between Vitamin D3 deficiency, metabolic syndrome, and VDR, GC, and CYP2R1 gene polymorphisms, so this study represents a reference one that it will be able to continue for other age groups or other categories of patients. The gene discussed is VDR; the disease is metabolic syndrome.