In ccRCC, glucose metabolism induced by HIF1 leads to an increase in solute carrier family 1 member 5 (SLC1A5), glucose transporter 1 or 3 (GLUT 1/3), and lactate dehydrogenase A (LDHA), thereby stimulating lactic acid production [42]. The gene discussed is LDHA; the disease is nonpapillary renal cell carcinoma.