Resveratrol, curcumin, (−)-epigallocatechin gallate, and cinnamyl alcohol [27,37,38,39] exhibit anti-obesity effects by inhibiting both the MAPK/ERK and PI3K/AKT signaling pathways and reducing the phosphorylation of ERK and AKT. This evidence concerns the gene AKT1 and obesity due to melanocortin 4 receptor deficiency.