It is possible that CA exhibits antitumor effects in PC-3 cells (lacking p53 expression) by increasing sestrin-2 levels independent of p53, similar to the effects seen in H1299 lung cancer cells [57] and to the effects seen with quercetin treatment of HCT116 and HT-29 colon cancer cells [95]. This evidence concerns the gene TP53 and malignant colon neoplasm.