Consistent with the existing literature reports, in this study, the expression of PLIN2 was significantly increased in the liver and skeletal muscle of obesity mice, while the expression of PLIN2 in the liver of obesity-resistant mice was markedly reduced compared to obesity mice (Figure 4B,E), leading to a decrease in lipid droplet synthesis. Here, PLIN2 is linked to obesity due to melanocortin 4 receptor deficiency.