This is because there are no mature adipocytes in the intercellular matrix of the skeletal muscle in obesity-resistant mice, only adipose precursor somatic cells that have not differentiated into mature adipocytes, while PLIN2 is not expressed on the surface of mature adipocytes but only in adipose precursor somatic cells [31]. This evidence concerns the gene PLIN2 and obesity due to melanocortin 4 receptor deficiency.